Results
| PMID | 12571183 |
| Gene Name | IGFBP1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 41 |
| Population details | 41 (12 minimal/mild endometriosis, 10 moderate/severe endometriosis, 19 tubal obstruction) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | IGF-1, IGFBP-1 and IGFBP-3 |
| Other associated phenotypes |
Female infertility, endometriosis |
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Hum Reprod. 2003 Feb;18(2):423-8. Cunha-Filho, J S L| Lemos, N A| Freitas, F M| Kiefer, K| Faller, M| Passos, E P Obstetrics and Gynecology Department, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil. BACKGROUND: Endometriosis is associated with pituitary-ovarian axis dysfunction. The study of the follicular fluid in patients with endometriosis is important to elucidate the pathophysiological mechanism of this disease. The objective of this present paper was to analyse the dosages of insulin-like growth factor-1 (IGF-1) and IGF binding protein-1 and 3 (IGFBP-1 and IGFBP-3) in the follicular fluid environment of infertile patients with endometriosis. METHODS: A total of 41 infertile patients undergoing IVF between January 1999 and January 2000 participated in the cross-sectional prospective study. Patients were divided into three groups: group I, minimal/mild endometriosis (n = 12); group II, moderate/severe endometriosis (n = 10); and group III, tubal obstruction (n = 19). The ultra-short protocol was used in association with recombinant FSH for ovulation induction. Follicular fluid analysis was performed using radioimmunoassay with specific kits. RESULTS: Follicular fluid IGF-1 and IGFBP-3 levels were not significantly different among the groups; however, follicular fluid IGFBP-1 levels were lower in those patients with moderate/severe endometriosis (P < 0.05). Comparison of ovulation induction time, number of recombinant FSH units, number of follicles, oocytes and embryos, and fertilization and gestation/cycle rates showed non-significant differences. CONCLUSION: Infertile patients with moderate/severe endometriosis, which is associated with ovulatory dysfunction, presented lower levels of IGFBP-1 in the follicular fluid when undergoing IVF. Mesh Terms: Adult| Cross-Sectional Studies| Endometriosis/*complications| Female| Follicular Fluid/*metabolism| Humans| Infertility, Female/*etiology/*metabolism| Insulin-Like Growth Factor Binding Protein 1/*metabolism| Insulin-Like Growth Factor Binding Pro |
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